Few visitors ever get a warning

The incidence and range of valley fever has grown dramatically over the last two decades, and some experts warn that the fungus is growing increasingly resistant to drugs—a phenomenon they say is due to the spraying of antifungal agents on area crops.

As annual cases continue to rise, local health officers have sought to increase awareness of the disease and its symptoms, which are often misdiagnosed. This messaging, however, focuses only on Kern County and other Central Valley locations and rarely reaches those who live outside Kern County, or other high-risk areas.

In the case of the Lightning in a Bottle festival, according to state health officials, 20 people were diagnosed with coccidioidomycosis in the weeks and months following the event. Five were hospitalized.

According to a statement provided by the California Department of Public Health, officials have been in communication with organizers and “encouraged” them to notify “attendees about valley fever and provide attendees with recommendations to follow up with health care providers if they develop illness.”

Do LaB, the company that stages the festival, said through a spokesperson that it adheres to the health and safety guidance provided by federal, state and local authorities. “Health and safety is always the primary concern,” they said.

The company’s website warns festival-goers about the prevalence of dust—but doesn’t mention the fungus or the disease.

“Some campgrounds and stage areas will be on dusty terrain,” the website says. “We strongly recommend that everyone bring a scarf, bandana, or dust mask in case the wind kicks up! We also recommend goggles and sunglasses.”

Kern County’s health department is also in discussions with the production company.

In California, the number of valley fever cases has risen more than 600% since 2000. In 2001, fewer than 1,500 Californians were diagnosed. Last year, that number was more than 9,000.

Most people who are infected will not experience symptoms, and their bodies will fight off the infection naturally. Those who do suffer symptoms, however, are often hard-pressed to recognize them, as they resemble the onset of COVID or the flu. This further complicates efforts to address the disease.

In April, Carrigan began getting a lot of headaches. Not really a “headache person,” she chalked them up to stress: Managing a high-profile public health job while also parenting two teenagers. But as the days and weeks went by, the headaches became more frequent, longer in duration and increasingly painful. She also developed an agonizing sensitivity to light.

“I’ve never experienced sensitivity to light like that … all the curtains in my house had to be closed. I was wearing sunglasses inside—because even the clock on my microwave and my oven, and the cable box … oh, my God, it caused excruciating pain,” she said. In order to leave the house, she had to put a blanket over her head because the pain caused by sunlight was unbearable.

She also developed nausea and began vomiting, which led to significant weight loss. Soon she became so exhausted she couldn’t shower without needing to lie down and sleep afterward.

Her doctors ordered blood work and a CT scan. They told her to get a massage, suggesting her symptoms were the result of tension. Another surmised her symptoms were the result of dehydration.

Eventually, it got so bad she was hospitalized.

When test results came in, her doctors told Carrigan she had a case of disseminated valley fever, a rare but very serious form of the disease that affects the brain and spine rather than the lungs. In retrospect, she said she probably had the disease for months.

And yet, here she was, arguably the most high-profile public health official in a county recognized as a hot spot for the fungus and the disease, misdiagnosed by herself and other health professionals repeatedly before someone finally decided to test her for the fungus.

Now she’ll have to take expensive antifungal medications for the rest of her life—medication that has resulted in her losing her hair, including her eyelashes, as well as making her skin and mouth constantly dry.

As a result of Carrigan’s experience, her agency is running public service announcements on TV, radio and in movie theaters. She does news conferences, talks to reporters and runs presentations for outdoor workforces—solar farms, agriculture and construction—to educate those “individuals that have no choice but to be outside and really disturbing the soil.” She’s also hoping to get in schools.

But she realizes her influence is geographically constrained. She can really only speak to the people who live there.

Outside of California, valley fever is also prevalent in Arizona and some areas of Nevada, New Mexico, Utah and Texas, as well as parts of Mexico and Central and South America.

Experts worry that as the range of valley fever spreads—whether by a changing climate, shifting demographics, or increased construction in areas once left to coyotes, desert rodents and cacti—more and more severe cases will appear.

They’re also concerned that the fungus is building resistance to the medicines used to fight it.

Antje Lauer, a professor of microbiology at Cal State Bakersfield and a “cocci” fungus expert, said she and her students have found growing pharmaceutical resistance in the fungus, the result of the use of agricultural fungicides on crops.

She said the drug fluconazole—the fungicide doctors prescribe off-label to treat the disease—is nearly identical in molecular structure to the antifungal agents “being sprayed against plant pathogens. … So, when a pathogen gets exposed via those pesticides, the valley fever fungus is also in those soils. It gets exposed and is building an immunity.”

It’s the kind of thing that really concerns G.R. Thompson, a professor of medicine at UC Davis and an expert in the treatment of valley fever and other fungal diseases.

“If you ask me, what keeps you up at night about valley fever or fungal infections?, it’s what we do to the environment” he said.

“We learned that giving chickens and livestock antibiotics was bad, because even though they grew faster, it led to antibiotic resistance. Right now, we’re kind of having our own reckoning with fungal infections in the environment. We’re putting down antifungals on our crops, and now our fungi are become resistant before our patients have ever even been treated.”

He said he and other health and environment professionals are working with various local, state and federal agencies “to make sure that everybody’s talking to each other. You know that what we’re putting down on our crops is not going to cause problems in our hospitals.”

Because at the same time, he said, there’s a growing concern that the fungus has become more severe in terms of clinical outcomes.

“We’re seeing more patients in the hospital this year than ever before, which has us wondering … has the fungus changed?” he said, quickly adding that health experts are actively investigating this question and don’t have an answer.

John Galgiani, who runs the Valley Fever Center for Excellence out of the University of Arizona in Tucson, is hopeful that a vaccine may be forthcoming.

He said a Long Beach-based medical startup called Anivive got a contract to take a vaccine that’s being developed for dogs—outdoor-loving creatures with noses to the ground and a penchant for digging, and therefore susceptible to the disease—and reformulate it to make it suitable for human clinical trials.

He said prison populations, construction workers, farmworkers, firefighters, archaeologists—anyone who digs in the soil, breaths it in or spends time outdoors in these areas—would be suitable populations for such inoculations.

But he, like everyone else The Times spoke with, believes education and outreach are the most important tools in the fight against the disease.

As there is with any other risky activity, he said, if people are aware, such knowledge empowers them with choice—and in this case, the tools they need to help themselves should they fall ill.

2024 Los Angeles Times. Distributed by Tribune Content Agency, LLC.