Sunday, December 29, 2024
Home Oncology & Cancer Pembrolizumab aids survival with high-risk endometrial cancer

Pembrolizumab aids survival with high-risk endometrial cancer

by Medical Xpress
0 comment



Pembrolizumab plus chemotherapy improves disease-free survival (DFS) in patients with high-risk endometrial cancer after surgery with curative intent, according to a study published online Oct. 16 in the Journal of Clinical Oncology.

Brian M. Slomovitz, M.D., from Mount Sinai Medical Center in Miami Beach, and colleagues conducted a protocol-prespecified of patients with mismatch repair-deficient (dMMR) from the phase 3 ENGOT-en11/GOG-3053/KEYNOTE-B21 study undergoing surgery with curative intent. The analysis included patients randomly assigned to pembrolizumab 200 mg or placebo (six cycles) plus carboplatin-paclitaxel (four to six cycles) every three weeks, then pembrolizumab 400 mg (141 patients) or placebo (140 patients) every six weeks (six cycles).

The researchers reported that an interim analysis showed DFS favored pembrolizumab (hazard ratio, 0.31), with median DFS not reached in either group. For pembrolizumab and placebo, two-year DFS rates were 92.4 and 80.2 percent, respectively. No new safety signals were reported.

“Preplanned subgroup analysis based on the study’s stratification factors suggests that pembrolizumab plus improves DFS and is clinically relevant for patients with dMMR tumors in the curative-intent setting,” the authors write.

Several authors disclosed ties to pharmaceutical companies, including Merck, which manufactures pembrolizumab and funded the study.

More information:
Brian M. Slomovitz et al, Pembrolizumab or Placebo Plus Adjuvant Chemotherapy With or Without Radiotherapy For Newly Diagnosed, High-Risk Endometrial Cancer: Results in Mismatch Repair-Deficient Tumors, Journal of Clinical Oncology (2024). DOI: 10.1200/JCO-24-01887

Copyright © 2024 HealthDay. All rights reserved.

Citation:
Pembrolizumab aids survival with high-risk endometrial cancer (2024, October 21)
retrieved 21 October 2024
from https://medicalxpress.com/news/2024-10-pembrolizumab-aids-survival-high-endometrial.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.





Source link

You may also like

Leave a Comment

Edtior's Picks

Latest Articles

All Rights reserved, site designed by Yellohost.co.za