A Cleveland Clinic research team has published the first study assessing the independent real-world impacts of weight loss and blood sugar control on clinical outcomes in people with type 2 diabetes treated with antidiabetic medications, and specifically with GLP-1RAs (the class of drug that includes Ozempic and Wegovy).
The study found that for every 1% decrease in BMI, regardless of change in blood sugar, there was a 4% decrease in cardiovascular risk. Further, blood sugar control, independent of weight change, was linked to a lower risk of chronic kidney disease. These findings are clinically meaningful and highlight the importance of treating people with type 2 diabetes for both glycemic control and obesity.
The retrospective findings, published in Diabetes, Obesity and Metabolism, used deidentified electronic health record-derived data from more than 1,300 patients with type 2 diabetes evaluated at Cleveland Clinic.
More information:
Anukriti Sharma et al, Elucidating the role of weight loss and glycaemic control in patients with type 2 diabetes, Diabetes, Obesity and Metabolism (2024). DOI: 10.1111/dom.15896
Citation:
Research assesses impact of weight loss and blood sugar control in type 2 diabetes (2024, September 18)
retrieved 18 September 2024
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